Oscar Nilsson

oscar.nilsson@gu.se

EDUCATION & EXPERIENCE

2021-Present
Ph.D. student in Medicinal Chemistry

University of Gothenburg
Sweden

2019-2021
MSc. in Medicinal and Organic Chemistry

University of Gothenburg
Sweden

2016-2019
BSc. in Chemistry

University of Gothenburg
Sweden

RESEARCH INTERESTS

My main interests are in developing small-molecule enzyme activators and inhibitors to act as drug compounds. My approach focuses on allosteric modulators for large tetrameric enzymes in the glycolytic pathway, which could provide new insight into protein modulation strategies and provide a platform for the development of novel antilipidemic agents.

PUBLICATIONS

Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators. Amalyn Nain-Perez, Oscar Nilsson, Aleksei Lulla, Liliana Håversen, Paul Brear, Sara Liljenberg, Marko Hyvönen, Jan Borén and Morten Grøtli. Eur. J. Med. Chem. 2023, 250, 115177.

Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase. Umberto Maria Battisti, Chunxia Gao, Oscar Nilsson, Fady Akladios, Aleksei Lulla, Agnieszka Bogucka, Amalyn Nain-Perez, Liliana Håversen, Woonghee Kim, Jan Boren, Marko Hyvönen, Mathias Uhlen, Adil Mardinoglu and Morten Grøtli. ChemBioChem. 2023, 24, e202200339.

Environmentally friendly catechol-based synthesis of dibenzosultams. Sara Liljenberg, Amalyn Nain-Perez, Oscar Nilsson, Josipa Matic, Morten Grøtli. New J. Chem. 2022, 46, 5593 – 5605.

Azulene functionalization by iron-mediated addition to a cyclohexadiene scaffold. Petter Dunås, Lloyd C. Murfin, Oscar J. Nilsson, Nicolas Jame, Simon E. Lewis, and Nina Kann. J. Org. Chem. 202085, 13453-13465.