Enzyme Inhibitors (EI)
Enzyme inhibitors are molecules that interact in some way with the enzyme to prevent it from working in the normal manner. We are developing kinase inhibitors and tRNA synthetase inhibitors to be used as tool compounds as well as potential lead compounds for drug development.
Lack of probe selectivity is a recurrent problem in pharmacological treatments and is caused by the inability to control the activity of the probe in time and space. We are addressing this issue by incorporating photoresponsive groups (photoswitches and photolabile protecting groups) into the molecular structure of kinase inhibitors. These inhibitors allow for the use of light to externally control activity, which can be delivered with very high spatiotemporal precision.
Fluorescent Nucleic Acid Base Analogues (FNABA)
Fluorescent nucleic acid base analogs (FBAs) are structural analogs of the standard DNA/RNA bases, which are highly fluorescent, and form Watson-Crick hydrogen bonds with complementary bases. We are developing FBAs for studying structure and dynamics of nucleic acids.