István Köteles

Postdoctoral Fellow

istvan.koteles@gu.se

EDUCATION & EXPERIENCE

2022-present: Postdoctoral Work

University of Gothenburg, Sweden

2015-2022: Ph.D. in Organic and Medicinal Chemistry

Semmelweis University, Hungary

2010-2015: M.Sc. in Pharmaceutical Sciences

Semmelweis University, Hungary

RESEARCH INTERESTS

I am upmost interested in medicinal chemistry and the application of various organic chemistry methods in the development of new pharmaceutical compounds. Currently I am working on the synthesis of allosteric modulators for pyruvate kinase liver isozyme utilizing fragment based drug design.

PUBLICATIONS

Simultaneous Determination of Enantiomeric Purity and Organic Impurities of Dexketo-profen Using Reversed-Phase Liquid Chromatography—Enhancing Enantioselectivity through Hysteretic Behavior and Temperature-Dependent Enantiomer Elution Order Reversal on Polysaccharide Chiral Stationary Phases. Máté Dobó, Gergely Dombi, István Köteles, Béla Fiser, Csenge Kis, Zoltán-István Szabó, Gergő Tóth. Int. J. Mol. Sci. 2024, 25, 2697.

Synthesis and biochemical evaluation of 17‑N‑beta‑aminoalkyl‑4,5α‑epoxynormorphinans. Ferenc Ötvös, Edina Szűcs, Ákos Urai, István Köteles, Pál T. Szabó, Zsuzsanna Katalin Varga, Dávid Gombos, Sándor Hosztafi, Sándor Benyhe. Sci. Rep. 2023, 13, 20305.

The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character. Dóra Csicsák, Rita Szolláth, Szabina Kádár, Rita Ambrus, Csilla Bartos, Emese Balogh, István Antal, István Köteles, Petra Tőzsér, Vivien Bárdos, Péter Horváth, Enikő Borbás, Krisztina Takács-Novák, Bálint Sinkó, Gergely Völgyi. Pharmaceutics 2023, 15, 278.

Species-specific acid-base characterization of carnosine and homocarnosine using nuclear magnetic resonance. Arash Mirzahosseini, Mirsadra Molaei, Károly Mazák, Tamás Pálla, István Köteles, Nikolett Varró, István Mándity, Béla Noszál. Chem. Phys. Lett., 2022, 808, 140128.

Synthesis of 3-O-Carboxyalkyl Morphine Derivatives and Characterization of Their Acid-Base Properties. István Köteles, Károly Mazák,a Gergő Tóth, Péter Horváth, Eszter Kiss, Boglárka Tűz, Sándor Hosztaf. Chem. Biodiversity, 2021, 18, e2100135

Enantioseparation of solriamfetol and its major impurity phenylalaninol by capillary electrophoresis using sulfated gamma cyclodextrin. Ida Fejős, Gergő Tóth, Bianka Várnai, Zoltán István Szabó, István Köteles, Milo Malanga, Szabolcs Béni. Electrophoresis, 2021, 42, 1818-1825.

Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants. István Köteles, Károly Mazák, Gergő Tóth, Boglárka Tűz, Sándor Hosztafi. Molecules, 2020,17, 4009.

Determination of the Enantiomeric Purity of Solriamfetol by High-Performance Liquid Chromatography in Polar Organic Mode Using Polysaccharide-Type Chiral Stationary Phases. István Köteles, Mohammadhassan Foroughbakhshfasaei, Máté Dobó, Márk Ádám, Imre Boldizsár, Zoltán‑István Szabó, Gergő Tóth. Chromatographia, 2020, 83, 909-913.