Cassandra Fleming

Postdoctoral Fellow

casfle@chalmers.se

EDUCATION

2011–2015          Ph.D. in Synthetic/Med. Chem.
                             Deakin University, Australia
2006–2010          B.A. in Forensic Science with Honours
                             Deakin University, Australia

RESEARCH INTERESTS

The development of light-responsive molecular tools for the study of disease progression in live cells and organisms. The design and synthesis of chemical entities capable of both therapeutic properties and imaging in potentially diagnostic sense (theranostics).

PUBLICATIONS

On the Use of Diarylmaleimide Derivatives in Biological Contexts: An Investigation of the Photochromic Properties in Aqueous SolutionC. L. Fleming, P. Remón, S. Li, N. Simeth, B. König, M. Grøtli, J. Andréasson, Dyes Pigments, 2017, 137, 410–420.

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation, Gaur, T. Connor, A. Sanigorski, S. D. Martin, C. R. Bruce, D. C. Henstridge, S. T. Bond, K. A. McEwen, L. Kerr-Bayles, T. D. Ashton, C. Fleming, M. Wu, L. S. P. Winer, D. Chen, G. M. Hudson, J. W. R. Schwabe, K. Baar, M. A. Febbraio, P. Gregorevic, F. M. Pfeffer, K. R. Walder, Mark Hargreaves, S. L. McGee, Cells Report, 2016, 16, 2802–2810.

Synthesis of N-substituted 4-Hydroxynaphthalimides Using Palladium-Catalysed Hydroxylation, C. L. Fleming, T. D. Nalder, E. H. Doeven, C. J. Barrow, F. M. Pfeffer, T. D. Ashton, Dyes Pigments, 2016, 126, 118–120.

A Fluorescent Histone Deacetylase (HDAC) Inhibitor for Cellular ImagingC. L. Fleming, T. D. Ashton, C. Nowell, M. Devlin, A. Natoli, J. Schreuders, F. M. Pfeffer, Chem. Commun. 2015, 51, 7827–7830.

Synthesis of 4-Amino Substituted 1,8-Naphthalimide Derivatives using Palladium-mediated AminationC. L. Fleming, T. D. Ashton and F. M. Pfeffer, Dyes Pigments, 2014, 109, 135–143.

Improved Synthesis and Structural Reassignment of MC1568: A Class IIa Selective HDAC InhibitorC. L. Fleming, T. D. Ashton, V. Gaur, S. L. McGee and F. M. Pfeffer, J. Med. Chem2014, 57, 1132–1135.