Umberto Battisti

Postdoctoral Fellow

umberto.battisti@chem.gu.se

EDUCATION

2015–2017          Lab manager & Postdoctoral fellow, Med. Chem.
                             Virginia Commonwealth University, USA
2012–2015          Postdoctoral fellow, Med. Chem. 
                             University of Modena and Reggio Emilia, Italy
2009–2012          PhD in Med. Chem.
                             University of Modena and Reggio Emilia, Italy
2009                    Qualification to practice as Pharmacist
                             University of Modena and Reggio Emilia, Italy
2003–2008          Master Degree in Chemistry and Pharmaceutical Technologies
                             University of Modena and Reggio Emilia, Italy

RESEARCH INTERESTS

During the years he was involved in several areas, from CNS diseases to viral and parasitic  infections. His work as a medicinal chemist has already resulted in several publications, seminars and conference communications. His main research interests including drugs design employing classical medicinal chemistry approaches, the design of multi-steps synthetic strategies and stereoselective synthesis.

PUBLICATIONS

Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists, Silvia Franchini, Leda Ivanova Manasieva, Claudia Sorbi, Umberto M. Battisti, Paola Fossa, Elena Cichero, Antonio Cilia, Elena Poggesi, Livio Brasili, Eur. J. Med. Chem2017, 125, 435–452.

Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides, Silvia Franchini, Umberto M. Battisti, Claudia Sorbi, Annalisa Tait, Andrea Cornia, Livio Brasili, Archives of Pharmacal. Res. 2017, 40, 537–549.

An unexpected reversal in the pharmacological stereoselectivity of benzothiadiazine AMPA positive allosteric modulatorsUmberto M. Battisti, Cinzia Citti, Giulio Rastelli, Luca Pinzi, Giulia Puja, Federica Ravazzini, Giuseppe Ciccarella, Daniela Braghiroli, Giuseppe Cannazza, MedChemComm 2016, 7, 2410–2417.

Analytical and preparative enantioseparation and main chiroptical properties of Iridium (III)bis(4,6-difluorophenylpyridinato)picolinato, Cinzia Citti, Umberto M. Battisti, Giuseppe Ciccarella, Vincenzo Maiorano, Giuseppe Gigli, Sergio Abbate, Giuseppe Mazzeo, Ettore Castiglioni, Giovanna Longhi, Giuseppe Cannazza, J. Chromatogr. A, 2016, 1467, 335–346.

“Heart-cut” bidimensional achiral-chiral liquid chromatography applied to the evaluation of stereoselective metabolism, in vivo biological activity and brain response to chiral drug candidates targeting the central nervous systemUmberto M. Battisti, Cinzia Citti, Martina Larini, Giuseppe Ciccarella, Natalia Stasiak, Luigino Troisi, Daniela Braghiroli, Carlo Parenti, Michele Zoli, Giuseppe Cannazza, J. Chromatogra. A, 2016, 1443, 152–161.

7-Chloro-5-(furan-3-yl)-3-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-Dioxide as Positive Allosteric Modulator of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor. The End of the Unsaturated-Inactive Paradigm? Cinzia Citti, Umberto M. Battisti, Giuseppe Cannazza, Krzysztof Jozwiak, Natalia Stasiak, Giulia Puja, Federica Ravazzini, Giuseppe Ciccarella, Daniela Braghiroli, Carlo Parenti, Luigino Troisi, Michele Zoli, ACS Chem. Neurosci. 2016, 7, 149–160.

Scouting New Sigma Receptor Ligands: Synthesis, Pharmacological Evaluation and Molecular Modeling of 1,3-Dioxolane-Based Structures and Derivatives, Silvia Franchini, Umberto M. Battisti, Adolfo Prandi, Annalisa Tait, Chiara Borsari, Elena Cichero, Paola Fossa, Antonio Cilia, Orazio Prezzavento, Simone Ronsisvalle, Giuseppina Aricò, Carmela Parenti, Livio Brasili, Euro. J. Med. Chem. 2016, 112, 1–19

Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry, Leda Ivanova Manasieva, Umberto M. Battisti, Adolfo Prandi, Livio Brasili, Silvia Franchini, Synthesis 2015, 47, 3767–3775.

Synthesis and structure-activity relationships of triazaspirodecanone derivatives as nociceptin/orphanin FQ receptor ligands, Corrado Sandra, Umberto M. Battisti, Claudia Sorbi, Annalisa Tait, Valeria Camarda, Davide Malfacini, Girolamo Calò, Livio Brasili, Chem. Biol. Drug Design, 2015, 86, 447–458.

A New and Versatile Synthesis of 1,3-Dioxan-5-yl-pyrimidine and Purine Nucleoside Analogues, Claudia Sorbi Adolfo Prandi, Umberto M. Battisti, Silvia Franchini, Andrea Cornia, Annalisa Tait, Dominique Scholes, Livio Brasili, Synlett, 2015, 26, A–F.

Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purine Nucleoside AnaloguesUmberto M. Battisti, Claudia Sorbi, Antonio Quotadamo, Silvia Franchini, Annalisa Tait, Dominique Scholes, Livio Brasili, Euro. J. Org. Chem. 2015, 1235–1245.

Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1 and 5-HT1A receptor ligand: an In Vitro and Computational Study, Silvia Franchini, Annamaria Baraldi, Claudia Sorbi, Elena Cichero, Umberto M. Battisti, Federica Pellati, Piero Angeli, Antonio Cilia, Livio Brasili, MedChemComm, 2015, 6, 677–690.

Structure–Affinity/Activity Relationships at α1 and 5-HT1A Receptors of 1,3-Dioxolane-Based Ligands, Silvia Franchini, Umberto M. Battisti, Annamaria Baraldi, Adolfo Prandi, Paola Fossa, Elena Cichero, Annalisa Tait, Claudia Sorbi, Gabriella Marucci, Antonio Cilia, Lorenza Pirona, Livio Brasili, Eur. J. Med. Chem. 2014, 87, 248–266.

Design, stereoselective synthesis, configurational stability and biological activity of 7-chloro-9-(furan-3-yl)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide, Marina M. Carrozzo, Umberto M. Battisti, Giuseppe Cannazza, Giulia Puja, Aurelia Falchicchio, Serena Perrone, Krzysztof Jozwiak, Daniela Braghiroi, Carlo Parenti, Luigino Troisi, Bioorg. Med. Chem. 2014, 22, 4667–4676.

Development of an in vitro liquid chromatography–mass spectrometry method to evaluate stereo and chemical stability of new drug candidates employing immobilized artificial membrane column, Giuseppe Cannazza, Umberto M. Battisti, Marina M. Carrozzo, Addolorata S. Cazzato, Daniela Braghiroli, Carlo Parenti, Luigino Troisi, J. Chromatogr. A, 2014, 1363, 216–225.

Synthesis, enantiomeric separation and docking studies on spiropiperidine analogues as ligands of nociceptin/orphanin FQ receptorUmberto M. Battisti, Sandra Corrado, Claudia Sorbi, Andrea Cornia, Annalisa Tait, Davide Malfacini, Maria Camilla Cerlesi, Girolamo Calò, Livio Brasili, MedChemComm, 2014, 5, 973–983.

1,4-Dioxolane-triazaspirodecanone derivatives as nociceptin/orphanin FQ receptor ligands, Corrado Sandra, Claudia Sorbi, Annalisa Tait, Umberto M. Battisti, Valeria Camarda, Davide Malfacini, Girolamo Calò, Livio Brasili, Med. Chem. Res., 2014, 23, 4642–4656.

Transacetalization of acetals with 1,2,4-butanetriol by means of Cobalt(II) Chloride and TrimethylchlorosilaneUmberto M. Battisti, Claudia Sorbi, Silvia Franchini, Annalisa Tait, Livio Brasili, Synthesis 2014 , 46, 943–946.

Regioselective cyclization of chloroacylaminobenzenesulfonamide derivatives, Marina M. Carrozzo, Umberto M. Battisti, Giuseppe Cannazza, Cinzia Citti, Carlo Parenti, Luigino Troisi, Tetrahedron Lett2012, 53, 3023–3026.

Efficient synthesis of 5,6-dihydro-8H-[1,2,4]thiadiazino[6,5,4-de]phenanthridine 4,4-dioxide and 5,6-dihydro-8H-[1,2,4]-thiadiazino[6,5,4-ij]thieno[2,3-c]quinoline 4,4-dioxideUmberto M. Battisti, Marina M. Carrozzo, Giuseppe Cannazza, Daniela, Braghiroli, Carlo Parenti, Livio Brasili, Cinzia Citti, Luigino Troisi, Tetrahedron Lett2012, 53, 1122–1125.

5-Arylbenzothiadiazine Type Compounds as Positive Allosteric Modulators of AMPA/Kainate ReceptorsUmberto M. Battisti, Kzrysztof Jozwiak, Giuseppe Cannazza, Giulia Puia, Gabriele Stocca, Daniela Braghiroli, Carlo Parenti, Livio Brasili, Marina M. Carrozzo, Cinzia Citti, Luigino Troisi, Med. Chem. Lett2012, 3, 25–29

Molecular modeling studies, synthesis, configurational stability and biological activity of 8-chloro-2,3,5,6-tetrahydro-3,6-dimethyl-pyrrolo [1,2,3-de]-1,2,4-benzothiadiazine 1,1-dioxideUmberto M. Battisti, Marina M. Carrozzo, Giuseppe Cannazza, Giulia Puia, Luigino Troisi, Daniela Braghiroli, Carlo Parenti, Kzrysztof Jozwiak, Bioorg. and Med. Chem2011, 19, 7111–7119.

Evaluation of stereo and chemical stability of chiral compounds, Giuseppe Cannazza, Umberto M. Battisti, Marina M. Carrozzo, Livio Brasili, Daniela Braghiroli, Carlo Parenti, Chirality, 2011, 23, 851–859.

Quantitative analysis of acetylcholine in rat brain microdialysates by liquid chromatography coupled with electrospray ionization tandem mass spectrometry, Marina M. Carrozzo, Giuseppe Cannazza, Diego Pinetti, Vittoria di Viesti, Umberto M. Battisti, Daniela Braghiroli, Carlo Parenti, Mario Baraldi, J. Neurosci. Methods, 2010, 194, 87–93.

Epimerization and hydrolysis of 3,6-dimethyl-2,3,5,6-tetrahydro[1,2,4]thiadiazino[6,5,4-hi]indole 1,1-dioxide, Marina M. Carrozzo, Giuseppe Cannazza, Umberto M. Battisti, Daniela Braghiroli, Luigino Troisi, Carlo Parenti, J. Chromatogr. A, 2010, 1217, 8136–8145.

Regioselective reduction of 3-substituted 2,3-dihydrobenzothiadiazines with borohydridesUmberto M. Battisti, Giuseppe Cannazza, Marina M. Carrozzo, Daniela Braghiroli, Carlo Parenti, Francesca Rosato, Luigino Troisi, Tetrahedron Lett2010, 51, 4433–4436.

Determination of kinetic parameters of enantiomerization of benzothiadiazines by DCXplorer, Giuseppe Cannazza, Marina M. Carrozzo, Umberto M. Battisti, Daniela Braghiroli, Carlo Parenti, Alessandro Troisi, Luigino Troisi, Chirality, 2010, 22, 789–797.

Simultaneously determination of enantiomerization and hydrolysis kinetic parameters of chiral N-alkylbenzothiadiazine derivatives, Marina M. Carrozzo, Giuseppe Cannazza, Umberto M. Battisti, Daniela Braghiroli, Carlo Parenti, Chirality, 2010, 22, 389–397.

On-line racemization by high-performance liquid chromatography, Giuseppe Cannazza, Marina M. Carrozzo, Umberto M. Battisti, Daniela Braghiroli, Carlo Parenti, J. Chromatogr. A, 2009, 30, 5655–5659.

PATENTS

1,2,4-Benzothiadiazine dioxide derivatives as allosteric modulators of AMPA receptor and their preparation and use for treatment of mnemocognitive disorders, Umberto M. Battisti, Giuseppe Cannazza, Marina M. Carrozzo, Carlo Parenti, Daniela Braghiroli, Giulia Puja, Luigino Troisi, Kzrysztof Jozwiak. European Patent Application (2012), EP 2457906 A1 20120530.