Fady Akladios

Postdoctoral Fellow

fady.akladios@chem.gu.se

EDUCATION

2013–2016          PhD studies
                             Charles Sturt University, Orange NSW, Australia
2009–2011          MPhil in Med. Chem.
                             School of Pharmacy, University of Sydney, Sydney, Australia
2010                    Registered pharmacist in Australia
                             Pharmacy Board of NSW examination
2005                    Bachelor degree in Pharmaceutical Sciences
                             Ain Shams University, Egypt

RESEARCH INTERESTS

 

PUBLICATIONS

Effects of linker elongation in a series of N-(2-benzofuranylmethyl)-N’-(methoxyphenylalkyl)-piperazine σ₁ receptor ligands, Moussa I.A, Banister S.D, Akladios F.N, Chua S.W, Kassiou. M, Bioorg. Med. Chem. Lett. 2011, 21, 5707–5710.

Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I, F. N. Akladios, N. A. Nadvi, J. Park, J. R. Hanrahan, V. Kapoor, M. D. Gorrell, W. B. Church, Bioorg. Med. Chem. Lett. 2012, 22, 1579–1581.

Selective induction of oxidative stress in cancer cells via synergistic combinations of agents targeting redox homeostasis, F.N. Akladios , S.D. Andrew, C. J. Parkinson, Bioorg. Med. Chem. 2015, 23, 3097–3104.

Improved Cytotoxicity of Pyridyl- substituted Thiosemicarbazones Against MCF-7 when used as Metal IonophoresF.N Akladios , S.D. Andrew, C. J. Parkinson, BioMetals 2016, 29, 157–170.

Increased generation of intracellular reactive oxygen species initiates selective cytotoxicity against the MCF-7 cell line resultant from redox active combination therapy using copper-thiosemicarbazone complexesF.N. Akladios, S. D. Andrew, C. J. Parkinson, J. Biol. Inorg. Chem. 2016, 21, 407–419.

Investigation of cytotoxic implication of different metal chelators against Melanoma and different approaches to improve the cytotoxicity profiles of metal coordinating agentsF.N. Akladios, S. D. Andrew, C. J. Parkinson, BioMetals2016, 29, 789–805.

Cytotoxic Activity of Expanded Coordination Bis-Thiosemicarbazones and Copper Complexes Thereof, F. N. Akladios, S. D. Andrew, C. J. Parkinson, J. Biol. Inorg. Chem. 2016, 21, 931–944.